1. Allergic reactions
Adverse reactions caused by antibiotics are very common. The main reasons for allergic reactions are the patient's individual constitution, the drug itself, impurities in the drug, and may also be caused by the metabolites of the drug. The types of allergies mainly include: ① allergic shock; ② Hemolytic anemia; ③ Serum diseases and drug fever; ④ Untyped anaphylaxis: The clinical manifestations are mainly skin rash, angioneurotic edema, fixed erythema, severe erythema, such as penicillin, tetracycline, streptomycin, and lincomycin.
2. Toxic reactions
The toxic reactions caused by antibiotics can lead to changes in the body's function or organizational structure, leading to physiological and functional changes. They are often related to the dosage and duration of medication, especially drugs with low chemotherapy index, which have a small safety range and are prone to toxic reactions. Mainly including: ① Neurotoxic reactions; ② Ototoxicity, nephrotoxicity; ③ Liver toxicity; ④ Hematological toxicity; ⑤ Immune system toxicity; ⑥ Secondly, there are gastrointestinal toxicity and cardiac toxicity reactions, which can lead to gastrointestinal reactions, arrhythmia, myocardial damage, etc. in patients.
3. Heterogeneous reaction
Heterogeneity reactions occur in a small number of patients and are often related to genetic factors. The sensitivity to certain drug abnormalities caused by congenital inheritance is basically consistent with the inherent pharmacological effects of drugs. Most of it is caused by the lack of certain enzymes in the body, which hinders the metabolism of drugs in the body. If chloramphenicol and amphotericin B enter red blood cells, they can transform hemoglobin into denatured hemoglobin; For patients with normal enzyme systems, such reactions will not occur after taking medication.
4. Double infection
High doses or long-term use of antibiotics, especially broad-spectrum antibiotics, can lead to the growth and reproduction of other non sensitive bacteria when sensitive bacteria are killed or suppressed. The bacteria that cause new infections can be parasitic bacteria that are normally harmless to the body. Due to changes in the bacterial population, other harmless bacteria that can inhibit the growth of the bacteria are suppressed by drugs and transformed into pathogenic bacteria, or they can also be drug-resistant strains of the primary infection bacteria. The secondary infections that are more likely to occur when using broad-spectrum antibiotics include: Clostridium difficile enteritis, fungal enteritis, oral fungal infection, candida albicans vaginitis, etc.
As for the adverse reactions caused by antibiotics, it has been mentioned earlier that everyone must pay attention to the dosage and method of use when using antibiotics to avoid any impact on the body. Shanghai Qixin New Materials Technology Co., Ltd. was established in 2016 and is located in Shanghai, China. It is a high-tech enterprise dedicated to the development of new materials, process optimization, and the research and development of pharmaceutical intermediates and reagents. Its main businesses include 7-amino-3-chloromethyl-2-cephem-2-carboxylic acid p-methoxybenzyl ester hydrochloric acid (CAS: 113479-65-5), Parylene F, Parylene F (VT-4), and Cefnitrothiophene, At the beginning of its establishment, companies such as Nitrocefin have regarded technological innovation and research and development capabilities as their core competitiveness, and are determined to provide customers with good products and technical services with price and technological advantages.
