Pharmaceutical intermediates refer to intermediate products in the pharmaceutical process, which are an indispensable part of the pharmaceutical process. Pharmaceutical intermediates mainly include two types: raw material pharmaceutical intermediates and synthetic intermediates. Raw material pharmaceutical intermediates serve as the main source of pharmaceutical ingredients, while synthetic intermediates serve as auxiliary sources of pharmaceutical ingredients.
In the pharmaceutical intermediate market, common products provided by Qixin include plant-based cholesterol (CAS No. 57-88-5), plant-based cholesterol acetate (CAS No. 604-35-3), and cephalosporin (CAS No. 41906-86-9). These intermediates have important significance in drug synthesis and are widely used in various disease treatment fields, such as vaccines, tumors, antibiotics, etc.
1. Plant derived cholesterol acetate CASNo. 604-35-3 The chemical structural formula is as follows | 2. Plant derived cholesterol CASNo. 57-88-5 Chemical name: (3β)-cholest-5-en-3-ol. The chemical structural formula is as follows |
Safety characteristics of plant-based cholesterol
At present, all cholesterol products in the market are sourced from animal sources, such as animal brain, spinal cord, tissue, lanolin, etc. Animal derived products have certain characteristics, such as easy spoilage of raw materials, possible presence of endogenous residues or exogenous pollutants (such as proteins, microorganisms, viruses, pesticides, veterinary drugs, etc.), unclear composition and/or proportion, and unique harmful ingredients to the human body (such as prion proteins), which may affect the consistency of products between batches and even cause unpredictable adverse reactions after use.
The Use of Plant Derived Cholesterol
Cholesterol has a wide range of uses and can be used as a cosmetic raw material, medicinal excipient, starting material for synthesizing vitamin D3, and feed additive, in various industries such as pharmaceutical and chemical production. Plant derived cholesterol has dispelled concerns about the risk of carrying animal viruses and expanded its use in the pharmaceutical industry.
3. Cefnitrothiophene CASNo 41906-86-9
The chemical structural formula is as follows
Cefnitrothiophene is a widely used chromogenic cephalosporin substrate used for detecting the presence of bacteria β- Lactam enzyme. Also known as 6- (2-nitrophenyl) -3 ', 5' - diphenylcarbamoyl-4 methyl-2-oxo-2H-pyran-3 carboxylicacid, it is a chromogenic cephalosporin substrate used for detection β- Lactam activity in bacteria.
Cefnitrothiophene is widely used as a diagnostic tool in microbiology laboratories to detect the presence of clinically isolated bacteria β- Lactam enzyme, which can endow β- Resistance to lactam antibiotics such as penicillin and cephalosporin.
In the β- In the presence of lactam, cefnidazole is bright yellow, making it a useful, cost-effective screening tool for rapid identification of antibiotic resistant bacteria. In addition, it is effective for detecting β- Lactam enzyme has high sensitivity and specificity, making it a valuable tool for monitoring emerging antibiotic resistance in clinical environment.
Characteristics of Cefnitrothiophene:
1. High sensitivity: Cefnidazole against β- Lactam enzyme activity is highly sensitive, which means that it can even detect micro enzymes that may not be detected by other tests.
2. Specificity: Cefnidazole is effective against β- The specificity of lactam enzyme means that it will not react with other enzymes or compounds that may exist in bacterial samples.
3. Speed: Cefnidazole produces visible color changes within a few minutes after detection, making it a fast and effective identification method β- Methods of lactam enzyme activity.
4. Cost-effective: Cefnidazole is relatively inexpensive and widely used, making it a cost-effective choice for laboratories.
5. Multifunctionality: Cefnidazole can be used to detect various bacteria β- Lactam enzyme activity, including those that may affect β- Lactam antibiotic resistant bacteria.
Overall, Cefnitrothiophene is used to detect bacteria β- Lactam enzyme activity is an important tool, which has many advantages compared with other detection methods.
